In the beginning, Sasori would most likely have to take care of the problem at hand; Samehada. This chakra eating symbiotic sword is the main problem for Sasori, taking care of this weapon is the first step into pressuring Kisame, and ultimately defeating him in the midst of battle. How exactly will Sasori counter Samehada:
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Samehada has shown properties into showing signs of being alive (eating chakra, disdainful reactions to Katon, favor over another host etc.) enabling me to propose that Samehada in fact is alive, and of course reacts with its host;
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Symbiont: an organism living in symbiosis
Symbosis: Close association of animals or plants: a close association of animals or plants of different species that is often, but not always, of mutual benefit.
Mutually beneficial relationship: a cooperative, mutually beneficial relationship between two people or groups.
Now that the establishment of Samehada being alive is presented, I can go on with my counter against it:
Sasori was very adept in poison formally developing a poison in which killed his victim in three days, with paralysis as a side effect,
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. Kisame has been shown to expose Samehada's bodily features very often (against Gai, and Bee etc.) thus, leaving Samehada open for wounds, or in general exposure to Sasori's lethal poison.
Due to Sasori starting in Hiruko this gives him an even more advantage as every technique he possesses while using Hiruko is poison covered (
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):
All weapons installed in Hiruko were coated in Sasori's special brand of poison, which would kill the victim after three days of painful paralysis.
- Extendible iron tail provided offence by stabbing and defence by rotating around the body.
- Heavy back shell for additional defence.
- Rapid launching of senbon from the mouth.
- Torpedo-shaped left arm that launches shrapnel of senbon in all directions.
Kisame has also been seen to block attacks using Samehada I believe (Kisame's more over a tank). So due to Kisame's speed disadvantage, and not knowing about Sasori's abilities in this fight he'd have no other way of countering other than blocking which would be Samehada's, and most likely his own downfall.
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)
Kisame is simply cornered by poison, along with Samehada being paralyzed and dying (within 3 days) due to it being that of an organism.
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* Underlined text are manga page links.
* This is my introductory argument.