Kakuzu vs Tsunade

[ItachiStyle]

Based on the distance Tsunade can move in 1-2 seconds, and the number of tasks she can complete while moving, and her general reaction time and awareness, it's pretty clear Tsunade will be very able to get close enough to hurt him. And that's without even considering Katsuyu. She'll be on Kakuzu before can has time to do much of anything, and once she's within striking distance he's toast.