If Kakashi has Obito's chakra they probably win, but otherwise they lose.
I restricted Plot no Jutsu , so I doubt that they would win even with MS Kakashi
Naruto and Sasuke individually can already hold their own against Kaguya. Together they've shown the ability to push her. With Kakashi (and Sakura), who makes Yomotsu Hirasaka, and thus separation, irrelevant, they have the potential to beat her, especially considering that Black Zetsu isn't here so she won't attempt to kill for a while.
kaguya neg dif sasuke every time he tried to attack her by himself + he didn't even able to touch her