Itachi's "unknown" disease -- Discovered

[Reboryushon]

I disagree.

1) Could be cancer.

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"Eating away at him from the inside..:"

2) Most probably Tuberculosis, which had a huge impact in Japan. It actually marked their society during the first half of the century (End of the 19th century) like HIV marks ours now, so it would be no surprise if Kishi based himself on this.

 

[Nobel]

Shinobi's are humans, and possess the same bodily functions we do, this is blatantly shown -- Of course this is aside from body altering techniques given to very few. Itachi had no body modifications similar to the majority of ninja in the NV.

Therefore, my logic is sound.


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Wrong, they are only called humans however it's a technical error to justify their autonomy by normal standards. Hence the clear difference in the multiple sources of energy they can use naturally, by infusing chakra with a certain sign they manipulate matter itself . Not only that but also create things out of nothing. You are overconfident in your measurements which lead to this arrogant act, humans of this world are "homo sapiens" because of their own physical abilities and history that evolved them to this day. In fact from the very sub-atomic construction of NV lies the clear difference in these two worlds, they are humans by literal sense but in reality there is an universal difference between us.

So in all of honesty, the analysis you provided is flawed to the core. But i still appreciate the sight of a rare thread...especially in this dying forum.

 

[Pretentious]

I disagree.

1) Could be cancer.

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"Eating away at him from the inside..:"

2) Most probably Tuberculosis, which had a huge impact in Japan. It actually marked their society during the first half of the century (End of the 19th century) like HIV marks ours now, so it would be no surprise if Kishi based himself on this.

I'd contemplated that as well years ago however, MPA completed the puzzle more so.

Wrong, they are only called humans however it's a technical error to justify their autonomy by normal standards. Hence the clear difference in the multiple sources of energy they can use naturally, by infusing chakra with a certain sign they manipulate matter itself . Not only that but also create things out of nothing. You are overconfident in your measurements which lead to this arrogant act, humans of this world are "homo sapiens" because of their own physical abilities and history that evolved them to this day. In fact from the very sub-atomic construction of NV lies the clear difference in these two worlds, they are humans by literal sense but in reality there is an universal difference between us.

So in all of honesty, the analysis you provided is flawed to the core. But i still appreciate the sight of a rare thread...especially in this dying forum.

From your perspective you believe humans in the NV are designed different via arbitration. Yet the fact Kishimoto made such with our exact body composition further proves humans in the NV aside from the genetically altered are capable of current world sickness, thinking otherwise is asinine.

Hence, why we've seen ninja sneeze, and get colds. What would you say those colds are? Some unknown "ninja flu" that truly sounds like a "strawman" argument. I appreciate the discussion however.

 

[Nobel]

I'd contemplated that as well years ago however, MPA completed the puzzle more so.


From your perspective you believe humans in the NV are designed different via arbitration. Yet the fact Kishimoto made such with our exact body composition further proves humans in the NV aside from the genetically altered are capable of current world sickness, thinking otherwise is asinine.

Hence, why we've seen ninja sneeze, and get colds. What would you say those colds are? Some unknown "ninja flu" that truly sounds like a "strawman" argument. I appreciate the discussion however.

Exact body composition? This is not about designs in matter of discussion. My point is about the techincal error within the thread itself, you may see these creatures as humans by litteral naming sense and appearance. But that is just an delusion, the fact alone that they are capable of these supernatural feats proves they work in a sub-atomic/cellular way differently.

Sneezing, getting colds are biological reactions that are simple and common with mammals. But this is not enough to define them as humans from this world.

 

[Risuna23]

Nice thread and I can't wait for the Kimimaro thread

 

[Amenotejikara]

amazing that a disease accomplished what sasuke and orochimaru failed at for years.

 

[Uzumaki Death god]

Aids > Itachi

Aids > Itachi

Naruto has universal healing

Naruto > Aids

Therefore

Naruto > Itachi

 

[SenseiSama]

I have to disagree, Kishi pointed at the reason being because if his chakra. Itachi didn't have the body for the level of eye power he possessed.

His chakra was stronger than CM Senjutsu which has been known to corrode human body, and use of MS has been known to take a toll on the body as well.

His weakening body was most likely a result of using his power to its limits, likewise I would say the same for Hashi and his overuse of Mokuton.

 

[Sagebee]

Itachi was into some weird kinky shit

 

[Warlocks]

that Diseases may be caused by over use of ms

 

[Darth AniCetuS]

Plot killed him.

 

[JStar King]

In August 23, 2009 I'd contemplated on putting together a thesis on what Itachi's disease actually was, but indeed I'd been much too indolent to accomplish such; yes, it took me nigh a full year to produce my perspective diagnosis, but such was an accurate resolution in the end -- Formerly published from my former "residence" back when I was quite new to the aspect of Naruto, until I discovered other forums of more profound intellect.

Anyhow, I'm rambling; Itachi's diagnosis: Microscopic Polyangiitis or MPA -- But for a more simpler put notion; Hemoptysis.

---

Back in August, I started seriously asking myself the question - what disease does Itachi have? When the internet couldn't give me anything better than 'advance-the-plot-itis,' I decided to take matters into my own hands.

After months of intense research, I think it's finally time to give Itachi Uchiha a REAL diagnosis... microscopic polyangiitis.

In short, MPA is a rare form of systemic vasculitis. It is an auto-immune disorder, characterized by antineutrophil cytoplasmic antibodies attacking the small vessels, causing them to bleed as they become damaged and inflamed. It can have far-reaching consequences throughout different organ systems that, when compared to Itachi's mysterious sickness, is nothing short of startling.

The most visible symptom of Itachi's illness is hemoptysis.

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The hemoptysis is, more likely than not, a result of diffuse alveolar hemorrhage. This is a classic symptom of MPA when it presents with pulmonary manifestations. There is also shortness of breath, and coughing.

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Unlike many other forms of vasculitis, such as wegener granulomatosis for example, the upper respiratory tract is usually spared. All the damage is deeper in the lungs. Itachi's case is consistent with this.

Other symptoms along the same vein can be seen during his final battle with Sasuke when Itachi grabs his shirt, reacting to what appears to be a heart attack.

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Chest pain, myocardial infarction and other signs of cardiac failure are not uncommon effects of this disease, especially considering how it presented.

It is also no secret that by the time of his death, Itachi was nearly blind. This, we know, to be a direct result of the mangyeko sharingan. When the mangyeko is used, it clearly puts a tremendous amount of strain on the eye, and the nerves and blood vessels that surround it. Needless to say, it's inflammatory in and of itself. But it is hasty to assume that Itachi's eye problems are caused by the mangyeko alone.

Ocular involvement in MPA is uncommon, but can exist - usually in the form of retinal hemorrhage and scleritis. The bloodshot eyes Itachi sports in his final battle with Sasuke show these symptoms clearly.

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And given this, it's no stretch to assume that MPA played a large role in accelerating the damage the mangyeko did to his eyes, hastening his vision loss.

Those are the only clues to Itachi's symptoms given outright in canon. But we can extrapolate others from the way he conducts himself.

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His low stamina as reported by the databook suggest constitutional symptoms of malaise and fatigue. The peculiar way he rests one hand in his cloak could be an attempt to alleviate painful sensations attributed to peripheral nervous system involvement manifesting as mononeuritis multiplex or myalgia, or simply to support a weakened limb. One could probably even argue his thin stature is evidence of weight loss.

There are, of course, come classic manifestations of MPA that cannot be observed in Itachi. This, however, dos not mean that they can't be rectified.

One of the most common ways MPA manifests itself is with renal involvement. We have no evidence that Itachi's kidneys have been damaged by disease. However, it is possible the damage is there, and simply did not produce outward, observable symptoms. At least half the cases of MPA also report skin involvement. This can range from small blisters to necrosis and gangrene. There are reports, however, of MPA only causing splinter hemorrhages, or small areas of bleeding under the nails. As the Akatsuki always wear nail polish, this would be completely unobservable.

Long story short, the symptoms fit. In fact, they're pretty much textbook.

Next, we consider what we know about how the disease was managed. Madara describes Itachi's disease to Sasuke in one panel.

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There, he reveals that Itachi took a variety of different medicines to keep himself alive. He could easily be describing the treatment of MPA, which requires a combination of different steroids and immunosuppressive agents. Because treating the disease requires suppressing his immune system, Itachi likely needed other drugs as well, including specific types of antibiotics and vitamins. Considering the high mortality rate of untreated microscopic polyanglitis, (a five-year survival rate of under 25%) this really did have the purpose of prolonging his life. Madara did not lie.

Lastly, we consider the prognosis.

The average age of onset is usually in the fifth decade of life, but cases around Itachi's age have been reported in medical literature. The cause of the disease is currently unknown. It is seen as an auto-immune disorder, but because it doesn't have a tendency to run in families, it's not viewed as genetic. (Sasuke, after all, is still healthy.) However, it is theorized that there needs to be a trigger event, such as a disease or a major bout of inflammation that sets the production of antibodies into overdrive. This trigger could easily be the initial, or repeated, activation of the mangyeko sharingan, which as stated before, is clearly inflammatory in and of itself.

The natural course of the disease fits cleanly into the time line of canon events as well. It is conceivable that, in the period of time following the chunin exam arc, he fell victim to the disease in full force. His whereabouts are unknown during the time-skip, where he likely managed to control it through medication, go into remission and then relapse again. That relapse would be the deciding factor in seeking out his final battle with Sasuke. The time between induced remission and relapse is usually around 2 years if it occurs, again fitting nicely with the chronology of the canon universe. And his death at Sasuke's feet is thus, easily explained.

Already came out with this thread a while back :lol

 

[GreyWizard93]

My idea was that when or used the uzumaki shrine to gain the mask to undo the reaper seal he said their would be consequences if done wrong plus he needed a new host. It'd make sense for the uzumaki clan to be on possession of the sealing items totsuka and yata and when Itachi found this out he feared others would to so he in the long term sacrificed his life and would entrust them to his brother who he loved more than anyone.

 

[Rohan]

The thread is nice but it's potential is wasted as the audience in this forum is garbage level in criticism and this can be seen very well by a majority of the replies in this thread.

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[Arian]

ive read this before way back on another site and it was also reposted/linked on nb before. so either youre just stealing someones work or are the actual original writer (which i doubt) lol

 

[Reboryushon]

I'd contemplated that as well years ago however, MPA completed the puzzle more so.

If it was MPA, Itachi wouldn't be able to fight since muscles are also affected. I believe this is very farfetched and Kishi wouldn't know what MPA is but it is your opinion and it should be respected.

Nice thread anyway!

 

[Pretentious]

Already came out with this thread a while back :lol

ive read this before way back on another site and it was also reposted/linked on nb before. so either youre just stealing someones work or are the actual original writer (which i doubt) lol

If you read the entry post it clearly states when I conceived the idea, then conjured it into written text etc. etc. Rather you believe I've written this article or not it affects me little, as stealing Naruto related documents would be pointless.

 

[The Work]

Just another overpowered character dying in a BS way.

 

[Guitar Hero]

Good thread.

 

[JStar King]

ive read this before way back on another site and it was also reposted/linked on nb before. so either youre just stealing someones work or are the actual original writer (which i doubt) lol

Yeah, it was my thread. I came out with it saying that Itachi's illness was most likely Hemoptysis.

:lol

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