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He used ms in every fight he was in this series excluding the body double( because he couldn't use it) obito said madara got sick from over using ms. Even sasuke was coughing up blood from overuse
Itachi got Aids from Shisui...
?_?
Really ?
Who is Zebra?
Itachi using MS definitely did take a toll on him, the same when it did for Sasuke too.
But Obito also stated that he had a terminal illness, so it wasn't only using MS. If you compare what he had to real life, the only symptom we saw was him coughing up blood-it looked like Tuberculosis or Cardiovascular disease (not aids trolls). But in reality, it was just plot-disease. Kishimoto probably didn't even know what it was, he just wanted to nerf him.
Also, he didn't overuse it. He actually maintained it the longest when you compare him to the other MS users who have both their eyes. And he didn't use it in every fight. He didn't use it against Deidara or Orochimaru.
The only side effect of MS usage is eventual blindness.