First of all I think she's gonna troll Madara, catch him off guard, and get off a really direct attack on him. But unfortunately I don't see how she can survive this fight. Not by that attack by Madara, I think her new regeneration technique will have no problem with that. But I think the regeneration technique will kill her. I mean when we first saw tsunde's powers shizunne explained that the technique slowly killed her. Well she I'd it then, fighting orochimaru, again against pain and now (assuming this regelation technique has the same effect on tsunade)
So NO I don't think Madara killed her with that attack, YES sadly I think this fight will kill her.