You basically said nothing in terms of actual arguments. Sasuke easily keeps up and overwhelms her in CQC as he has kept up with MS Itachi, someone a good way above her in striking speed and taijutsu expertise, plus had kenjutsu and precog skills with 3T that allowed him to fend off Bee's 8-sword-dance, at least for a while. Tsunade won't ever land the one hit she needs on him unless you can show me otherwise, especially not in his CM1 or CM2 state. All forms of speed are increased, but what gives Sasuke the win is his much greater reach thanks to his sword, plus he can also
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to temporarily impair Tsunade and cut her apart in that window, not that he needs it. One limb gone is basically gg for Tsunade. Sasuke can also summon a number of other snakes to help in his offense which makes this even more of a slaughter. Manda is a given, which by itself is enough, but that also gives him access to all other snakes Oro possessed, as proven by
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. That means he can summon these: [
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][
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][
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].