The only thing that's goten close to anoying me as much as the Sharingan is Hashirama's DNA.
Thank goodness there's only five Sharingan left in the world. I mean, three if Madara finally dissapears. Someone just take a kunai and cut out Tobi and Sasuke's eyes.
As far as Hashirama's DNA? The only person who's used it for any good at all is Hashirama himself! Tobi's a walking senju zit. One undred and one white Zetsus, and one black Zetu. Danzo used it, being the dousche that he is... or, was...). Orochimaru used it for Edo Tensei against the Third and IT'S IN MADARA'S BODY RIGHT NOW.
The Sharingan and Senju DNA have caused more trouble than good.