the most exciting thing i can see happen is sasuke becoming hokage before naruto, and naruto just standing there...WTF sasuke i did all this to you and you take my dream?! xd trollolo
I don't think Sasuke will still try and destroy Konaha. Him and Naruto will still fight though. They have to. They want to. It's been like that since the beginning.
I think that he will change his mind while fighting Naruto. One of the main themes of manga is conflict between two of them. It would not make sense if someone else finished it (not even Itachi). It would be weird if he just came to Naruto saying "Hey dude, about that fight I've promissed you...well, I've changed my mind... High five?"
I don't see him changing his mind because if you read the latest manga you will see why. Itachi basically told Sasuke he had no attachments to the world, not only that but Itachi never got to the "talk" with Sasuke. So after Itachi ends the Edo Tensi and vanishes, Sasuke will be left alone with even more hate. So I believe he will continue down his path of destruction. Personally I don't care if he changes his mind or not because I still say he is the best villan out there.
I don't think he's a good villian. Good villians are calm, wise, foxy and manipulative, like Tobi. Sasuke is rather reckless and a bit stupid. He would make the good villian if he kept his Taka attitude and clear mind. His easily controlled and used by other villians.