If all the 5 Hokage are to go at it...

[TehMastermind]

Depends, if 4th can tag Hashi then him, if not then Hashi

 

[Ovan]

No telling. All I know is that first two down would be the 3rd and Tsunade.

 

[DoubleKamui]

This question is a joke. Hiruzen solos all with his neutralizer jutsu.

 

[AGoodBoy]

Good thing you restricted it to only the first 5 hokage... If only you added the 6th hokage to this lineup, it could've been a more interesting street fight U_U

Hashi wins.