I believe Madara and Obito can take almost ANY 2v2 in the anime/manga.

[TheAwesomeOne]

Now lets have a list of what they can do:
Amaterasu-Unburnable through normal means
Tsukiyomi- One of the strongest genjustu in the NV
Susano'o: Has perfect form which is comparable to Bijuu
Kamui: Sends you a completely different dimension
Deva Path: Ability to push/pull (Telekinesis I guess)
Preta Path & All of the others: Absorbs chakra based techniques; Robotic Qualities(Asura); Rip souls & read minds(Human); Bring people back to life (Naraka); Summonings(Animal)
Meteorite Technique: Combination of Susano'o and Deva Path to pull a meteor to earth (Theirs)
Advanced Katon: Obito and Madara have both shown excellent Katon mastery
Almost All Basic 5 Elements(Except Raiton)
Moukuton: Grants Madara the power to use Hashirama's signature element
Chakra Constrictors(?(The things Tobi used to supress a Bijuu's power)
Intangibility
S/t Instant Teleportation
So on and so forth more to name but too many but on to what I was saying..

Madara and Obito basically can kill almost everyone except maybe Sasuke, Naruto, Itachi, SO6P(Obv), and I might be missing 2 more

Now if you really think about it Madara has Susano'o and Meteors and stuff so he could be a distraction or just take them on and Obito could warp them or just kill them;

If you don't think they can tell me why....

Btw I'm a little tired so I didn't really give a good example

 

[ITACHIUCHIA101]

hashi and minato would be pretty beast

 

[OnPoint]

Thought that was obvious enough :/

 

[ninjastormgenaration33]

Hashirama&Naruto can take them
Itachi&Nagato can take them
Minato&Sasuke have a chance

 

[10023213]

minato and hashirama or minato and hiruzen

 

[Unorthodox]

naruto sasuke nuff said

 

[Dęvîa Puęrî]

Honestly I might be over exgurating but with madara imortal/infinite stamina and chakra and Tobi with his pre jubbi (plus Kakashi has no more kuami left)
These two could take out naruto team team kage(cuz they wouldn't just let him leave they prob right behind him) and sasuke team (oro jugo suijutsu) all together and I'm not trolling perfect Susanno and pre jubbi is too much hax for one team and I thought team kage together was haxxed shit-_-

 

[Unorthodox]

pre juubi is weak unable to defend himself tobi saved it from kamui and killerbee punch

 

[Stark]

SO6P can possibly solo, and Elder Son and Younger Son can PROBABLY take them.

 

[RikudoKami]

Madara, The Unstoppable Force + Obito, The Immovable Object = Wrath of the Gods.

 

[Minator93]

LOL anything would sound great if presented in such a format.

Following pairs can take them on

1. Minato and Hashirama
2. Nagato and Minato
3. Hashirama and Nagato
4. BM Naruto and EMS Sasuke [Yes they have a chance]
5. BM Naruto and Nagato

Also -

Shisui SOLOs U_U
Kabuto with ET should SOLO

 

[Simple Math]

LOL anything would sound great if presented in such a format.

Following pairs can take them on

1. Minato and Hashirama
2. Nagato and Minato
3. Hashirama and Nagato
4. BM Naruto and EMS Sasuke [Yes they have a chance]
5. BM Naruto and Nagato

Also -

Shisui SOLOs U_U
Kabuto with ET should SOLO

bm naruto/nagato or hashirama/nagato have a great chance however the rest will get fkd up hard