Pain Arc
General
When Danzo loses control of the 1st Hokage's cells in his arm that were letting him use wood releases, his arm grows into a tree and nearly absorbs him into it before he rips it off to get away. Now consider how the fifty infants Orochimaru did the same thing to probably died. It'd only be worse if there was a small grove of little trees somewhere in Orochimaru's lab.
Horror
Pain's plan to build a nation-killing superweapon. It's not the weapon itself that causes the fridge horror, but what he intends to do with it. He plans to nuke hidden villages to scare everybody into laying down their arms — fine so far, albeit a bit on the crazy side. What makes it horrifying is the next aspect — he expects that this is not a permanent solution to war, but only one that will last until people forget how horrible this weapon is, at which point nations will once again wage war and use this weapon on each other. Hey Kishimoto, how long has it been since the Nagasaki bombing?
The idea is that when using it, you can instantly memorize pretty much anything, such as jutsus in the middle of a fight. Most likely, you'd only use the Sharingan in battle. It stands to reason that at some point, a veteran Uchiha would have seen a friend or close relative die in combat. That Uchiha would remember how that person died, in perfect detail, for the rest of his or her life. As you age, some memories start to fade. Instead of remembering when let's say, Cousin Ichijou managed to paint the cat pink, you'd recall the moment a kunai split her head in two. At some point in old age, all you would remember is violence and the deaths of your loved ones. Now consider just how many battles Madara had fought in... This also hugely justifies Sasuke's horror as a child. As his memories of childhood obscure in adolescence, his trauma has no chance of fading. It's his first permanent memory.
Tl;dr, each paragraph is a bracket that explains some huge plot points that may not come together if you were reading on a weekly basis.
Quite the "Yo Mama" Joke
Pain taunts Naruto, who is in the 4-tailed state, asking if Naruto hates him and if he still believes that people can be able to truly understand one another. Only that Naruto, while indeed furious, is under a Heroic B.S.O.D. and Kurama's at the reins. However, given later developments, it turns out Kurama is legitimately pissed as Pain is mocking the ideals of Kurama's creator and father figure, the Sage of the Six Paths. To which he reacts by forcing more chakra through the failing seal to go into the six-tailed mode. Tsunade is the Hero of this Arc.
The only reason why most of the people survived Pain's wrath was because of Katsuyu and Tsunade counteracting most of the damage he's inflicted thus far. Chou Shinra Tensei (the giant one) only had survivors because of Katsuyu. Pain also killed many people regardless and, while he did later revive them all he only had enough to revive those that he killed. If Tsunade didn't put herself in a coma, then chances are the death toll would be in the thousands. General
Crimes against humanity.
In the End, Konoha pardons Sasuke for his crimes against the village, but everywhere else, he is likely regarded as equivalent to Hitler. He tried to murder every single one of the Kages acting during the Kage Summit Arc, indirectly killed thousands by delivering Bee to the Akatsuki, and caused enormous destruction in the Land of Iron, severing a landmark, and likely causing a severe headache for the NORMAL people trying to commence trade. Putting things into perspective.
When Danzo loses control of the 1st Hokage's cells in his arm that were letting him use wood releases, his arm grows into a tree and nearly absorbs him into it before he rips it off to get away. Now consider how the fifty infants Orochimaru did the same thing to probably died. It'd only be worse if there was a small grove of little trees somewhere in Orochimaru's lab.
Horror
Historical Parallels
Pain's plan to build a nation-killing superweapon. It's not the weapon itself that causes the fridge horror, but what he intends to do with it. He plans to nuke hidden villages to scare everybody into laying down their arms — fine so far, albeit a bit on the crazy side. What makes it horrifying is the next aspect — he expects that this is not a permanent solution to war, but only one that will last until people forget how horrible this weapon is, at which point nations will once again wage war and use this weapon on each other. Hey Kishimoto, how long has it been since the Nagasaki bombing?
Perpetual Trama
The idea is that when using it, you can instantly memorize pretty much anything, such as jutsus in the middle of a fight. Most likely, you'd only use the Sharingan in battle. It stands to reason that at some point, a veteran Uchiha would have seen a friend or close relative die in combat. That Uchiha would remember how that person died, in perfect detail, for the rest of his or her life. As you age, some memories start to fade. Instead of remembering when let's say, Cousin Ichijou managed to paint the cat pink, you'd recall the moment a kunai split her head in two. At some point in old age, all you would remember is violence and the deaths of your loved ones. Now consider just how many battles Madara had fought in... This also hugely justifies Sasuke's horror as a child. As his memories of childhood obscure in adolescence, his trauma has no chance of fading. It's his first permanent memory.
Tl;dr, each paragraph is a bracket that explains some huge plot points that may not come together if you were reading on a weekly basis.
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