How does one kill Orochimaru?

UchihaMifune

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its a matter of techniquality

The fact of the matter is, Rasen Shuriken Still remains the most dangerous weapon against biological creatures.

No I believe that would be deidaras C4
 

Murasame

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Orochimaru admitted that God Summon Katsuyu can kill him.
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xxSAGExx

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Like completely kill him, get rid of him, to the point where he isn't coming back.

I'll start it off: Direct hit from TBB would kill orochimaru

Manga proof:

What else would do the job?

I was going to use the tbb, There's sealing him with the Totsuka blade, a direct hit from FRS (Tsunade, who Oro went to for his arms to be healed stated she couldn't heal wounds from a FRS that's about 50% completed) and , Jiraiya turning him into a toad would make him harmless , Jiraiya's toad stomach maybe since it can melt you as it crushes you (even Kisame and Itachi didn't want to stay inside it ), mini tbb that KM/BM can use in their hands , Bijuu laser that 8 tails and juubi used, Death reaper seal, slash from PS might wipe him out, Mei's and Son Goku's lava melts him, Dust release, Juubito's black Jinton like jutsu, Nagato's soul pulling jutsu and CT, Kamui takes him out of the equation, Amaterasu if he's hit in the face so he can't use oral rebirth, the sealing weapons that belonged to the Sage, and the Sage's sword.

All I could think of so far
 

xxSAGExx

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TBB would kill the orochimaru standing there, not orochimaru overall.

You would have to kill every curse seal holder along with that main body, and the amount of people who have the curse seal is probably more than you could ever hunt down.

Well Orochimaru can't be revived without someone else combine Orochimaru's flesh with his chakra then use the unsealing jutsu to revive Orochimaru like Sasuke did. Kabumaru doesn't exist since Oro took all trace of his power from Kabuto so unless someone else is walking around with Oro's DNA, he wouldn't be able to be revived. Only his chakra and consciousness/will is in the CM but he wasn't shown to even be talking to anyone with the CM except Sasuke when Orochimaru was literally sealed inside Sasuke via his body transfer jutsu
 

Ovan

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Inject Sasuke with aids and let him have at it.
 
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