Wouldn't matter, Itachi adv in hand/foot speed. he'll inevitably defeat them both with his own suiton/clone releases. worst case scenario they use the mist but unlike pt1 kakashi, itachi clones already had unique ability feints to bait/counter it.
Itachi used genjutsu in 2v1 several times.
No..outlast excuse apply to those who are significantly faster, durable, immune or ridiculous amount of intel/terrain adv
