Kakashi med-diff.
Sasuke's primary weapon at that time was Chodori and its variants. All of Sasuke's lightning jutsu (except for Kirin, which would be too slow to execute) would be useless against Kakashi.
Kakashi, on the other hand, had "a thousand jutsu" at his disposal. Kakuzu arc Kakashi would've been able to defeat Hebi Sasuke just from using C- and B-rank jutsu because his genius intellect makes virtually any and all jutsu lethal. Not that Sasuke doesn't has a tactical mind. His intellect just doesn't hold a candle to Kakashi's.
And let's not forget about Kamui. Since Hebi Sasuke wouldn't have had knowledge of it, Kakashi would've used it at exactly the right time. Kamui GG. If it's a fight with killing intent, then Sasuke would get decaptitated. If it's a fight just to incapitate the other, then Kakashi would Kamui one of Sasuke's limbs.
With all that being said, I know that Sasukebase would never be convinced that Sasuke loses this one. It's okay though. Good luck in life being biased.