Its difficult to pinpoint it down to five changes, I don't know how much I can do with each change anyway...say though, if I could change the last fifty chapters I would cut Madara and Kaguya entirely and just make Obito the final threat. Redeem him from the whole Rin bull with something worthy of a final villain. Like, have him kill some people, have him be a real threat and actually succeed in casting the Infinite Tsukuyomi. Naruto though manages to escape because of the Bijuu chakra inside of him after meeting Hagoromo and drags Sasuke with him. The final battle would be them, maybe some more people too, versus Obito, who ultimately is proven wrong and has some sort of epiphany before he dies. Sasuke doesn't return to the village and we don't get a fight....yet, leave it for another time, like a separate movie or a different continuation from Boruto.
EDIT: You know, I typed this before I watched the video, but now that I see this...well, its not that different.