Evil Itachi theory!

[Hatsumomo]

Madara, Obito, Sasuke... they all used to be good guys before losing the most precious person in their life.
Madara was the Co-founder of Konohagakure who dreamed about a peaceful shinobi world...
Obito was simply a kind boy helping old people carrying their luggages, a person devoted to protect his friends and who wished to become Hokage...
Sasuke's dream was to become a member of the Kohoha Military Police Force in order to capture villains and protect others...
But after Madara lost Izuna, Obito lost Rin and Sasuke lost Itachi they all turned into extremely dangerous evil villains and all of them tried to destroy Konoha...
So, what do you think? Itachi would have had became evil too if he lose Sasuke?

 

[Netferarri]

Hell yeah, Itachi would then become the solo king if Sasuke dies

 

[ElementNami92]

That was his only family so I imagine, yes. He probably would've gone insane. He would do anything to protect his brother.

 

[Uchiha Josephus]

Hmmm ... idk, I think he already dealt with the loss of his best friend.

So he'd say something like "..." followed by "it couldn't be helped"

"Oh look! Biscuits! Mmmmmmm ..."

 

[Dribbles]

It would effect him, but Itachi's resolve is far too great for Sasuke's death to be enough to break him, especially that far into the Akatsuki's web.