I am a Tobirama's fan , so i will no totally objective , but i want give my opinion :bdpf:
We don't know Tobirama's full power , and Edo Tobirama wasn't to 100% of his capacity.
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Tobirama is the best suiton user , more powerful than Kisame suiton , so we can imagine how tobirama suiton is powerful.
And according to last databook , Tobirama control Katon , Doton and Raiton.
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Tobirama hasn't use his elementary jutsus against Obito because only senjutsu jutsus was effective against Obito , so Tobirama could just helped Naruto with his Hiraishin.
But against EMS Sasuke , Tobirama can use elementary jutsu.
Tobirama use Hiraishin , Sasuke can be surprised by this jutsu like Izuna. Even Juubito has been surprised by Hiraishin. So Tobirama can use Hiraishingiri against sasuke in surprise attack.
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Tobirama's taijutsu is better than EMS Sasuke taijutsu , because he is Senju , and Senjus are more physical than Uchihas.
Tobirama can evade Sasuke's Amaterasu with Hiraishin.
The only problem for Tobirama , is Sasuke's Susanoo.
The only "massive attack" known of Tobirama is Gojo Kibaku Fuda
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But i don't think that Gojo Kibaku Fuda can destroy Sasuke's Susano.
Maybe , Tobirama's Suiton Suidanha can cut Susano's body.
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And we mustn't forget that Tobirama is very smart , and experienced against Uchihas.
So , i think Tobirama win against EMS Sasuke , but with difficulty.