I actually think that Saukra has a fair chance against Edo-Madara. She doesn't know any sealing jutsu, but that's okay. If Madara were to send out meteorites again, Saukra could easily punch them away to another galaxy since she has such insane strength. Punching a mediorite to another galaxy would be no problem for her. Madaras taijutsu is decent, but that'd be no problem for her. She was great standing one on one against Sasoris 100 puppets, so just fighting one person would be a piece of cake for Sakura. Madaras Wood Style wouldn't be a problem for Sakura either since she could easily break the branches that Madara summons and if Madara would use Susanoo, Sakura could just throw him to another planet like Mario did to Bowser in Mario 64.
Here's how Sakura would beat up the Complete Susanoo:
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