-Unrestrict SS and it manhandles them.
-Hashirama has a chance in S2. But might lose.
1. If Mokujin enters CQC with them, it's over since they won't have time to charge any BD strong enough to take it out. They get raped in CQC alone since Mokujin dwarfs them both and is far more powerful than them physically.
2. If they do manage to break away and start charging a BD, Myojinmon comes down on their necks, stopping the charge and forcing them to drop their Avatars to escape. In that time, Hashirama can crush them with Mokujin or he can prep a flower world to knock them out.
3. Any BD that doesn't need a charge is smacked away with ease (since the far inferior BM Naruto can smack away 5 BD with his tails no less). The Bijuu sized one is caught and tossed right back at them, and Flash never happens.
Sasuke offers nothing but defense here. His offense is pathetic and not worth mentioning, and Naruto's offense is either too weak to phase Mokujin or too strong to be charged before Hashirama does something about it. The only way they win is if they can break away from Mokujin, and charge and fire Flash BD before Hashirama can use Myojinmon or catch up to them.