Nah, i think it can be mid/high diff for nagato/itachi, cuz Kisame Kakuzu and Sasori are really strong....
Out of those 3, I only see kakuzu as a problem, to be honest.
- Dojutsu users are sasori's nightmare as they can see his strings. That means they can better predict his movement, cut his strings to make his puppets immobile for some time, and see exactly what he has attached to his strings. On top of that, they can spot his core right off the bat. I don't see why bansho tenin + Asura doesn't end him quickly when it solo'd 2 perfect jins low diff.
- As for kisame, He's relatively easy, honestly. I think he's even an easier kill than sasori. Kisame's not relatively fast in the first place. Right off the bat, amaterasu, yasaka, tsukuyomi or totsuka can kill him. Otherwise, banshou tenin + preta can restrain and drain his entire chakra pool. If that weren't enough, Nagato's crab summon pressures him in the very lake kisame creates, distracting him long enough for nagato to just blitz in(using whatever he did to blitz behind bee) and soul rip. again, kisame's quick with his hands, sword play, and swimming But, other than that, The best he can do is barely dodge fast attacks. His evasion isn't all that good.
*If kisame uses WD, it's basically suicide for him because he can only use CQC in there. Nagato summons his crab to pressure him; banshou tenin's him and rips his soul out; drains his chakra ;impales him on asura; let's itachi susano'o stab him the second he reaches near (like what mads did to susano').
- Kakuzu would be a little more trouble because of all his hearts, domu and threads but He'd die eventually seeing as he'd eventually be left with himself and a few others against itachi and nagato. *i intentionally omitted countering his arsenal because it'd be too long...*
Seeing as how easily these, tougher guys of akatsuki, are dealt with, There's absolutely no hope for the entire team. Without a dojutsu user, they're all susceptible to genjutsu(let's assume kakuzu and sasori are immune, like his fans claim, since i can't be arsed). In fact, Deidara's a hindrance to them because itachi's genjutsu, on him, makes him deadly to his own team while Susano'o + deva path completely protects team dojutsu from his attacks.