it's unknown, the big 3 are related to each though :I
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yeah i know right... i was thinking that... perhaps Izuna was either the father of Mikoto or Fugaku...
Izuna was too young for that, and didn't have time with love because of all the strife they he had to endure in order to keep his clan afloat.
^this, this too is a great point, however in those times, it was of a warring states era, traditionally it is know that
, bringing forth children is a must, male children would be raised to become warriors that would carry on the family's name and legacy
thus you can see, madara having 4 brothers and hashirama having 2, possibly more that died in battle,
other proofs can be shown in the hashirama flashback that it was like that, children fought in wars and died in honor for their clan