Madara - Manages to control Hashirama and in this instance he forces him to fight Naruto while he fights Sasuke, fully well knowing that they are the only threats to him. In this instance, this is where Naruto and Sasuke surpass them. Naruto receives aid from the Bijuu and other Kurama and becomes the "new Rikudou" in order to finally defeat Hashirama (gaining possibly the Rinnegan) and Sasuke shows the true power of the Uchiha, unveiling a more powerful Perfect Susano'o coated with Enton, and a new EMS technique (Time control) that lets him win the fight). Madara then gets subsequently sealed once pierced by Sasuke's massive Enton Blade from his Perfect Susano'o.
Sasuke - Aids in winning the war and beats Madara on his own. Dark intentions still, and he flees the village once more amidst distrust once more from the village. Him and Naruto fight (Obvious Naruto win) and instead of Sasuke dying, he accepts that he can't do everything on his own and relinquishes his hatred, effectively ending the Curse of Hatred, once and for all. He aids in the final...
Orochimaru - After the war, nobody decides to take Obito's body to "burn" it. Orochimaru steals Obito's body and inherits his abilities and because a new Shadow as a villain once more, and Naruto+Sasuke must take on an Orochimaru with Rinnegan+Mokuton+Kamui ALL enhanced by Dragon Sage Mode.