Sasuke wins mid difficulty.
Even while occupied by Hidan who is dangerous in CQC and someone who is worthy of full attention in a fight, Kakashi dodged Atsugai (
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)(
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)(
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). Sasuke was
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which have a greater AoE than
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. He only started getting tagged by Deidara due to the
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hindering his movements. If all else fails, Sasuke tanked a C2 explosion at the cost of one wing (
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)(
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) but Kakuzu's DC is inferior so his fuuton can be tanked.
The katon + fuuton combination was avoided by Ino-Shika-Cho who are far inferior in speed to Hebi Sasuke so Sasuke easily evades that as well (
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)(
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).
Raiton gian is Kakuzu's fastest and deadliest attack that Sasuke can't simply tank but if
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, Sasuke can easily sidestep the linear bolts of lightning which is much easier to do than covering the distance between himself and Ino-Shika-Cho.
Sasuke could use his CS2 wings to jump in the air and glide over attacks especially when the location is a forest. Sasuke can
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this
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so jumping over Kakuzu's techs is no problem. Once in midair, Sasuke is susceptible to attacks but he can easily use his
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to swing around from tree to tree, evading Kakuzu, getting close to him and swinging to safe positions.
Sasuke's chidori sharp spear easily cuts through threads and can take down multiple hearts inside Kakuzu's body after
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.
Kakuzu may have greater range than Sasuke but with Sasuke's ability to dance around Kakuzu's attacks and utilize the cover from all the smoke, trees and debris that Kakuzu's ninjutsu will surely whip up to conceal himself. This will allow Sasuke to utilise his speed and take Kakuzu out, let alone his masks, all of whom will have their reactions reduced by the debris. Unlike Kakuzu, Sasuke has the sharingan which
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so all those obstructions noted above won't hinder Sasuke's own reactions.
I haven't even touched upon Sasuke's snake summons which can be used as meat shields to guard against Kakuzu's ninjutsu let alone Manda which can prove to be a strong fighter on its own, let alone Sasuke fighting alongside it.
I haven't even touched upon genjutsu which can be broken but still give Sasuke a window of opportunity to blitz Kakuzu and skewer him with chidori sharp spear. Then there is also Kirin which can be prepped if Kakuzu keeps on spamming Katon. It may not be nearly as strong as the one used against Itachi but it doesn't need to be anywhere near as strong.