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We assume the uzumaki blood came from the Senju blood.
why
because madara and the 1st had it out and madara consider that the second son's decendent.
the uzumaki's are known for long life and it could be possible that the uzumaki clan was formed before the senju clan was.
that and the first son had to of had more then just the uchiha to follow his blood line. where are they at? only other clan with eye power is hyuga clan.
No,because it is shown they knew they were distant relatives and had strong ties.