Your question is a bit ambiguous, does he fight them one a time and take out Akatsuki or he fights all of them at once?Could Hashirama take out the entire akatsuki by himself? If yes why? and if no why not?
How so? Hashirama is considered the strongest shinobi in history,and fought Madara multiple times.I doubt Genjutsu would work on him,plus Itachi's stamina isn't high.Itachi would win alone unless you give Hashirama intel. lolz.
- Itachi's genjutsu prowess >>>>>> Madara's. 3T Itachi literally lol diffs with a quick genjutsu that Hashirama can't detect and a blitz. If for some reason you don't agree, Tsukuyomi is still an option. He fought Madara but didn't bother avoiding his eyes, or Sasuke's don't see why Itachi should be any different. Don't agree with that? There's still Ephemeral.How so? Hashirama is considered the strongest shinobi in history,and fought Madara multiple times.I doubt Genjutsu would work on him,plus Itachi's stamina isn't high.
Nah,this isn't really worth debating.It's just that Hashirama has way more power than Itachi,plus seems not to be bothered by Genjutsu.The fact that he didn't avoid Madara's eyes shows Genjutsu wasn't a concern,but then again,we don't know if Madara had Tsukuyomi,and even if he did we know Itachi was the best at Genjutsu so it may work on Hashirama.- Itachi's genjutsu prowess >>>>>> Madara's. 3T Itachi literally lol diffs with a quick genjutsu that Hashirama can't detect and a blitz. If for some reason you don't agree, Tsukuyomi is still an option. He fought Madara but didn't bother avoiding his eyes, or Sasuke's don't see why Itachi should be any different. Don't agree with that? There's still Ephemeral.
- Stamina is irrelevant in a match that Itachi takes a few seconds to win.
I'll see your reply tomorrow, logging off.
What if he had The Great Second Hokage's help?individually? yes he would win...at once? he gets destroyed