Edo Itachi - with unlimited chakra, regenerating body, no illness, susanoo, amaterasu, yata mirror, totsuka blade, tsukoyomi and other strong genjutsu- takes this IMO. Hi simply paralyzed Oro once, he just has to amaterasu tsunade and take on Jiraiya or something like that. Though it would be very hard difficulty, and maybe the sannin win. But I'd say Itachi.