Naruto, Sasuke, Gaara, Hinata, Minato, Kushina, Kabuto, Itachi
This, but adding on Lee, Nagato, Yahiko, Haku, and Konan
Naruto: Had to grow being hated by all...except Hiruzen, Hinata, and later Iruka.
Sasuke: Family murdered ji brother to protect Sasuke....killed brother in revenge...haha psych!!!!
Gaara: Tough love from daddy....hatred from everyone else for a while.
Minato and Kushina: died to keep their son and village safe.
Haku: Father killed her.....his mother and tried to kill him. Killed his father. Never knew Zabuza truly cared for him. Died almost feeling like he'd failed his purpose.
Kabuto: Grew up living lies...killed his foster mother. Wad lost in copying Orochimaru
Itachi: Had to kill his family because of possible revolution.
Lee: Grew up being picked on for no shinobi talent
Amegakure Trio: Grew up war orphans. Konan and Nagato lost their lover and best friend respectively.
Hinata: Grew up being constantly hated by her own family. Also hated by her relatives for simply being born main branch. Couldn't make progress no matter how much effort she put forth.