The running theme so far has been the "Curse of Hatred" between the Uchiha and Senju.
But that has never been the true curse. The true curse was upon Kaguya for falling in love with the planet. Because of this, Hagoromo and his treachery were born.
Kaguya's love for the planet incited her to take actions that disrupted the natural relationship the Holy Tree had with the planet, as well as the role the Ototsuki play in the preservation of that balance. Kaguya's actions 'cursed' those who would become the Hyuuga, the Uzumaki - as well as created the Senju and Uchiha clans - as well as all of those who would inherit the chakra from Hagoromo's equally disruptive actions.