Edo Tobirama and KCM Edo Minato, if they both attack Double MS Obito in 2 vs 1 , they can win in high difficulty. With Hiraishin, they can escape Obito's Kamui. A combination between Tobirama and Minato is very deadly against anybody (except Ashura's and Indra's transmigrants). And against Susano, Edo Minato can use KCM 2, so it would be a Bijuu VS a perfect Susano, which is a fair fight, and Tobirama could help Minato by distracting Obito with all he can do. And don't forget that Double MS Obito has...MS and not EMS, so he couldn't overuse his eyes and especially his susano, while Edo Minato and Edo Tobirama could endure for long time this fight.
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And if Sasuke and Naruto, even without hagoromo power, join Edo Tobirama and Edo Minato. It's definitley over for Double MS Obito.