Raiden lobs her head off. Since it's not a raikiri variant it doesn't need sharingan.I'd say Tsunade high diff even without Katsuyu. Her regeneration feats are staggering and Kakashi can't use Raikiri or Chidori effectively without sharingan.
PS: Since Kakashi lost the sharingan does that mean all of the jutsu he has copied are lost as well?