Naruto - This is his childhood dream, to be acknowledged by everyone, becoming Hokage. He told multiple times that he won't die before he become Hokage. Now that he is acknowledged by everyone and called the Hero of the Leaf, one part of his dream is accomplished, and maybe he has the most chance of becoming Hokage right now, if Tsunade dies. But he's not that smart, he is currently the strongest Leaf ninja, but he'll encounter very tough times when it comes to paperwork, missions or anything like that.
Sasuke - After reuniting with Itachi and hearing Hashirama's story about the village and the ninjas, it looks like he finally chose the right way, to protect what Itachi gave his life for and inherit his will. Looks like he was pissed or something from the current situation which was made by any of the former Kage, so he decided to become Hokage and change the shinobi system, change Konoha etc. His idea isn't that bad, because it sure needs some changes, but the problem is that he is still considered as criminal, very little amount of people believe him, his power is acknowledged by everyone, but I don't think he himself is acknowledged, because of the things he did. Sure, the Hokages accepted him as a Leaf shinobi, his team is with him too, but I don't think this is enough to become Hokage after leaving his village, training under the guidance of one of the most dangerous criminals, helping Akatsuki to capture Bee, attacking the Summit and many others. Even though, he have any properties that are needed - he wants to protect the village, he is smart, cool, collected, most importantly, he is one of the strongest characters, he can handle the paperwork and other things like that, and I think he will be Hokage, but after some time passes, alongside Naruto, just like Hashirama and Tobirama.