After the IT is broken...

[EdoShinagami]

What's keeping Oro of using Edo Tensei and revive the Hokages again and strike...

If Sasuke is defeated, sealed or killed...what do you think he's gonna do? Lead Taka? Disappear? Be arrested?

 

[-ahhimane-]

marry Tsunade and live long

 

[EdoShinagami]

marry Tsunade and live long

Actually I would root for that pairing...haha

 

[Naruto X Hunter]

Sasuke won't die or be sealed.

Spoiler

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And Orochimaru deosn't have the Kages DNA.

 

[cmoG]

Oro's time has been gone a long time ago & like the other person above me stated, Sasuke will remain alive & well. The feud & cycle of hatred will be broken.