Oh for sure. Sasuke said Kaguya was twice as strong as Madara. (Let's say 2.5 times as strong)
Guy managed to own a Juubi-Jinchuuriki Madara using 8 gates... So the 8 Gates probably is an exponential power boost, not simply adding or multiplying. (This is all very rough assumptions, but they are fair)
I say the gates at least increase the person in strength 10 times (totally acceptable)
Juubi-Jinchuuriki Madara is probably twice as strong as Base Hashirama. So Kaguya should be four times as strong as Base Hashirama. Assuming I'm right in that the strength increases 10 times, Hashirama would be at the advantage