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So Itachi has a habit of going using Genjutsu right off the back? Particularly eye genjutsus usually. If you notice Tsunade has been battling Madara for quite a while now and has yet to look in his eyes. She's a senju who already knows about Sharingan genjutsu. The fact that his style is so consistent is what makes him more vulnerable as Tsunade has full knowledge. Databook stats aren't very reliable and are to be taken with a grain of salt. What really matters are cannon feats.
Well Itachi is a genjutsu specialist, whereas Tsunade is a taijutsu, evasion, and medical specialist. Kunai? Shuriken? These weapons seldom pose a threat to top tier fighters. When we're considering Exploding Clones Tsunade has Katsuyu.
Yes distance is in Tsunade's favor. She can immediately force Itachi into a taijutsu battle. Where do you get this crazy idea that in order to not look someone in the eyes while fighting you must look at their feet. I know as a martial artist I don't stare into someones eyes when I fight them nor do I stare at their feet.
It's not about setting up a scenario. It's about actually comparing the two based on their merits and abilities. Tsunade stomps three tomoe Itachi as she should be very capable of breaking through any attempt at genjutsu. She dominates in hand to hand. And without MS what does he have in his arsenal to sufficiently kill Tsunade?
