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well knowing that 2 of the Karma users were 3rd eye possessors, then yeah it makes sense. However Isshiki's existence throws a spanner in the works. Unless he is a transcendent one, which he isn't, then it shouldn't make sense. However, since Amado said that to plant the God Tree is to become...

I've said this before: It is most likely that Black Zetsu is Kaguya's Karma. It took over the White Zetsu that was born out of the Gedo Mazou (her own vessel).