IMO, If Sasuke and Karin had kids, they would be powerful.
>Red haired Sharingan Users
>Uzumaki Clan Jutsu
>Possibility of Rinnegan
>Body + Eyes
>Longevity
etc.
If Hinata and Naruto had kids, they would also be powerful.
>Black haired babies with Blue Eyes
>Uzumaki Clan Jutsu
>Might inherit...