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With restrictions Danzo can perhaps high difficulty, however if there are no restrictions Itachi will turn Danzo into a marshmallow with totsuka and melt him with Amaterasu.

Sasuke will mid difficulty scenario 1 and extremely high difficulty scenario 2. Won't be easy in either scenarios, however sasuke is an uchiha genius .

Itachi can win with high difficulty or it can be a draw. However itachi without his disease should be above Pain.