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Yeah he was artificially created,he's d only Akatsuki member that doesnt have a headband on and When Madara was explaining 10000 zetsu's to Kabuto he made mention of him creating Zetsu from the first Hokage DNA.

Yeah,since they were trained by the three Legendary sannins,they were also trained by their Sensei's to summon special partners.But I dont think Sasuke is that attached to Oros Manda,cos he hates anytin that has to do with Orochimaru.