Neji wins with mid-high difficulty as his taijutsu is a lot better than both of them. He is also a lot faster than the two.
He can easily take them out one by one and finish the fight like that. Sakura and Hinata, however, will try to fight him together in order to overwhelm him but Neji could avoid a 2 on 1 skirmish by moving away from them or by quickly catching one of them off guard, probably Sakura since she doesn't have the Byakugan's 360 vision.
Once one of them has been taken out, Neji should be able to win the fight.
His rotation means that even if both Hinata and Sakura come at him together, they get pushed away and Neji can use this opportunity to use vacuum palms to finish them.
Still we shouldn't underestimate Sakura's surprise traps that she may prepare such as sleeping gas bombs or her ability to throw Neji's balance off by punching the ground although this would also throw Hinata off.