Physical attacks are the most laughable in the face of Kamui. Obito can slip through any attack, effortlessly. With Tsuande's speed, he will hardly have to 'stay on his toes' as you wrongly claim, especially considering her movement is so linear. It required Minato to resort to Hiraishin's instant movement in order to slay an openly inexperienced Obito. Ē, even with the Raiton no Yoroi activated, already proved that he could not best Obito's intangibility [
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]. Tsunade isn't going to turn and 'rip off his hand' whilst her soul is being swiped.
Despite the fact that Madara taught Obito the Rikudō no Jutsu in addition to the forbidden Uchiha techniques. Despite the fact that he's already shown he can use Gedō (Outer Path) with a stronger binding than even Nagato and implied that he can use Ningendō [
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]. He pretty much confirmed that the other jutsu of the 6 paths were accessible to him, he simply chose not to call them forth because of the chakra expenditure (which would've been very high because of him simultaneously controlling the bijū) [
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]. That is not the case here, so he would be free to use whatever is necessary without consequence.