The Death Eater Seal will get released. Kurama will get back half his Chakra, saving Naruto from Edo-Madara.
Around the same time, Sasuke will get Senju DNA, thanks to Orochimaru, and proceed to unlock Rinnegan.
Not sure how Edo-Madara will be sealed/beaten, but if the Death Eater Seal is released, then a whole bunch of options open up for defeating him.
Naruto and Sasuke will battle the 10 Tails. With the Yang half of Kurama back Naruto will perform Yin-Yang Release splitting the incomplete 10 Tails back into the other 7 (8 if Bee gets killed somehow) Tailed Beasts, akin to the Sot6P.
Manga ends.