Let's say this near-mindless killing of Konoha is justified.
He's already an international criminal, if it wasn't for Tobi and his war the world would be after his head.
If he goes for Konoha, Gaara won't take this sitting down, that means Suna would be after him. With Onoki's newfound respect for Gaara, Iwa would probably join in as well. With Sasuke "capturing" Killer Bee in the past, A and Kumo would also join in. Theres no specific reason for Mei & Kiri to join, but being an international criminal is probably enough. And let's not forget the Samurai as well, for breaking into the Summit killing Samurai around, and for being somewhat allied with the ninja, that gives Mifune reason to join as well
It turns from Sasuke vs Konoha, to Sasuke vs Suna, Iwa, Kumo, Kiri, and the Samurai all at the same time.
Sasuke is going to die dragging the Uchiha name farther in the mud than its ever been.