I'm gonna say death is pretty much assured. OR she lives but ends up old and crusty like Hiruzen was and will need to choose a successor. It probably won't be naruto, but he will def be next after that. Naruto needs to learn and grow more, running a country at 16/17 seems like a horrible decision.
I think anyone who thinks that Tsunade would nominate naruto for hokage or if she died Naruto would become hokage should have their head examine.If Tsunade dies, which I doubt, Kakashi will become the Hokage for sure.Hero or not, no one wants Naruto at his current intelligence level running their village.
I think Tsunade will live. And you said Tsunade trained Sakura, yes, but is she any good like Naruto or Sasuke. She has medial ninjutsu but its not that great.