dude anything can be destroyed if you use more force on a technique than the chakra/power of technique itself, Susanoo is no exception.
Want examples?
1) Sasuke supressed his curse seal with none that sheer mind-power.
2) Sasuke broke through Itachi's Tsukuyomi
3) Sasuke broke through Danzos seal with Susanoo level 2
4) Naruto broke through Deva Pein's "chakra rod" body mind/body manipulating technique by unleashing kyuubi.
5) Edo Nagato's meteor technique was beaten by the combined effort of perfect jins like Naruto, Bee and Itachi's attacks = their combined chakra exceeded Nagato's chakra.
However, Mei don't have the same powerful chakra as Sasuke so I don't think she will be able to melt an EMS invincible haxx perfect Susanoo that is actually two (maybe 3?) notches above the base Susanoo.
You Sir, are Just a SASUKE Fan...
On a more serious note, Where do you base your assumption that Mei does not have as much chakra as Sasuke ? She is a Kage, if you have forgotten...
And have you read the Manga at all ? She has 3 kekkei Denkai..
THREE !!!
That in itself talks about the Humongous amounts of Chakra that she has...
Just having more than one Kekki Denkai would need shit load of Chakra...
So not enough chakra is a totally wrong assumption...
As for Sasuke, this thread is about Sussano and not "SASUKEEE" (As Ino would call out, in the academy time series..)
Yet, for your benefit, i would like to point out that Sasuke's sussano might not have been perfect, but all the Sussanno that we have seen, in the Whole Manga, came WITH Side-effects...
So even the "Puuurfect" Sussanno, of your 'beloved' Sasuke will have its side-effects...
The only benefit that sasuke gets from having his brother's eyes, is that he doesn't go forever blind after the use of the EMS for a said period of time...(As stated by Madara, in the looking back chapter.)
All other effects would still be around...
That means, a very heavy toll on the User's Chakra stores..