I don' think so. If anything he can use Izanagi, to make the alliance believe he is sealed, but I doubt it can break him free from it.
Koto (Shisui) genjutsu is totally different and even when Izanagi was shown it was stated the Koto was the strongest of all genjutsu. Koto was pretty much set to manipulate/force someone into the genjutsu that will protect the village. Where as Izanagi is casted on the user itself to make the opponent imagine something else. I can't imagine it to break free from edo, as of yet in anyway, unless there is more info on the tech.
First of all, there is a dispute about the strongest genjutsu. Zetsu said it was itachi's tsukuyomi. Also tobi wants to use this genjutsu to control the world.
Tobi said its izanagi because of what it does, especially what the sage did with this tech.
Itachi said its koto amatsu kami.
All these techs are ridiculous and tbh this shows that there is no such thing as the 'strongest', genjutsu or ninjutsu.
Anyway on the point ive highlighted in your sentence. The user does cast the tech on themselves, But it doesnt make the opponent imagine something else, it just turns reality into dreams and dreams into reality