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They did. And while after Sakura tries to kill him under the bridge Kakashi even confirmed that Sakura's poisoned Kunai won't work as Oro would've made sure that any of Tsunade's poison doesn't work on Sasuke. Its not just one but 2-3 times in the manga.
Part 1 Sasuke didn't need drugs to reproduce Lee's feat in weeks when it took Lee years. He never needed drugs to perform OP feats and you would be a hater for claiming he did.