Yeah it's basically energy. Not living cells. Byakugou permisses cell regeneration. It heals internal and external organs.
Now the issue is the chakra circulatory system being an actual traffic of vein and all. Is it embedded like the pulmonary veins that carry the blood?
So gentle Fist closes off tenketsu, will cell regen heal this so called tenketsu and open it again? I dont think so.
I prefer the scenario where this separate chakra bank of sakura reopens closed tenketsus... similar as what Kurama did.
Although Kurama is a separate conscious being, I would tolerate this possibility
***Yin seal Chakra is used to hasten cell duplication for rapid regenration... Tsunade said so herself...so what if this chakra is disrupted?