EMS Sasuke's performance against SM Madara seemed superior to Tobirama's who was trashed by SM Madara after attempting a blindside attack whereas EMS Sasuke's reflexes were commended by SM Madara's, so in CQC, EMS Sasuke (Post-Juubito fight) could potentially defeat Tobirama in CQC.
If not, he always has his V3/V4 Full-Body Susano'o to fall back on which should enable him to tank all of Tobirama's attacks.
C'mon you forgot that Madara had 1 Rinnegan against Tobirama?