Orochimaru was the most nerfed character...

[SageOro]

-Researches jutsus his whole life, but can't use them the whole series because his arms are sealed
-Gets sealed by Totsuka Blade, which Itachi just seems to have out of nowhere (The only counter to Kusanagi)
-Spends 3 years to train Sasuke then gets attacked on his bed while having an almost dead body
-We never saw him fighting seriously, because he either wants to take the body of someone or just play around
-Learns Sage Mode, but can't use it because his body is too weak...

 

[Complex]

Madara surpassed Orochimaru with characters that have been nerfed the most

 

[super yang]

^ awesome set

 

[ANiMUS]

Kaguya has all chakra, but can only use a hand full of jutsu

 

[Sasori]

He's not nerfed just weak/

 

[Monxstaa]

-Researches jutsus his whole life, but can't use them the whole series because his arms are sealed
-Gets sealed by Totsuka Blade, which Itachi just seems to have out of nowhere (The only counter to Kusanagi)
-Spends 3 years to train Sasuke then gets attacked on his bed while having an almost dead body
-We never saw him fighting seriously, because he either wants to take the body of someone or just play around
-Learns Sage Mode, but can't use it because his body is too weak...

if you are going say Oro was nerfed then i guess people will say sakura was nerfed

 

[Gerkak]

Kaguya was the most nerfed character

 

[Mohamed Nabil]

Actually every character in the manga was nerfed... except for Naruto

 

[Ripple Hole]

Yea Oro was nerfed af, I just find it ironic how a Sasuke fanboy disagrees
when they're the main ones complaining plot & nerf at Sasuke not using more paths.

Yet Oro has studied justu for years of his life and achieved a list of things he hasn't
used.:lol Oro has the worst luck ever, whenever he gets something, whatever he
needs to use it is taken away from him.

 

[Fockboy]

-Researches jutsus his whole life, but can't use them the whole series because his arms are sealed
-Gets sealed by Totsuka Blade, which Itachi just seems to have out of nowhere (The only counter to Kusanagi)
-Spends 3 years to train Sasuke then gets attacked on his bed while having an almost dead body
-We never saw him fighting seriously, because he either wants to take the body of someone or just play around
-Learns Sage Mode, but can't use it because his body is too weak...

nope lord itachi is. he solos oro.

 

[Fockboy]

Actually every character in the manga was nerfed... except for Naruto

one off the top of my head is his speed bijjudama feat.